Treatment of Acute Malaria with Pyrimethamine

Extrapyramidal syndrome after treatment of falciparum malaria with sulphadoxine-pyrimethamine.

Therapeutic Uses of Vitamin E Treatment of Acute Malaria with Pyrimethamine Sir,-the Paper

SIR,-The leading article on "The Therapeutic Uses of Vitamin E" (December 20, 1952, p. 1345) certainly calls for comment by us, the proponents of the use of a-tocopherol in cardiovascular disease. Such an article might conceivably have been written in 1948 or 1949. However, the picture has changed so rapidly since that time that your leading article now simply does not reflect the findings of i...

Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy

For monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase and dihydrofolate reductase genes of Plasmodium falciparum parasites contrasts with the efficacy of sulfadoxine/pyrimethamine in reducing low ...

Atovaquone and proguani hydrochloride compared with chloroquine or pyrimethamine/sulfodaxine for treatment of acute Plasmodium falciparum malaria in Peru.

The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (Malarone) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru. Patients were initially randomized to receive 1,000 mg atovaquone and 400 mg proguanil hydrochloride daily for 3 days (n=15) or 1,500 mg chloroquine (base) over a 3 day per...

Randomized Trial of Piperaquine with Sulfadoxine-Pyrimethamine or Dihydroartemisinin for Malaria Intermittent Preventive Treatment in Children

BACKGROUND The long terminal half life of piperaquine makes it suitable for intermittent preventive treatment for malaria but no studies of its use for prevention have been done in Africa. We did a cluster randomized trial to determine whether piperaquine in combination with either dihydroartemisin (DHA) or sulfadoxine-pyrimethamine (SP) is as effective, and better tolerated, than SP plus amodi...